Code
NTG-BTPX-02CX
Profile
Active-Compendium
81457x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE Breast Tumor Profile characterizes primary or metastatic breast tumors of any histological subtype for the most significant genetic changes relevant to therapy decisions, prognosis, and clinical research. <br><br>
This profile analyzes <b>61 biomarkers</b> through a combination of next-generation sequencing (NGS), FISH, and IHC. Test reports include summary interpretation of all results to help guide treatment decisions.<br><br>
<b>NGS: (54 genes + MSI and TMB)</b><br>
A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available.<br><br>
<b>FISH (3 biomarkers):</b><br>
MET, PTEN<br>
(tech-only available)<br><br>
<b>IHC (2 biomarkers)</b><br>
* PD-L1 22C3 (tech-only available)<br>
* Pan-TRK <br>
Reflex rule: If Pan-TRK IHC is expressed or equivocal, we will reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1–3 FISH Panel will be added.</p>
This profile analyzes <b>61 biomarkers</b> through a combination of next-generation sequencing (NGS), FISH, and IHC. Test reports include summary interpretation of all results to help guide treatment decisions.<br><br>
<b>NGS: (54 genes + MSI and TMB)</b><br>
A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available.<br><br>
<b>FISH (3 biomarkers):</b><br>
MET, PTEN<br>
(tech-only available)<br><br>
<b>IHC (2 biomarkers)</b><br>
* PD-L1 22C3 (tech-only available)<br>
* Pan-TRK <br>
Reflex rule: If Pan-TRK IHC is expressed or equivocal, we will reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1–3 FISH Panel will be added.</p>
Orderable Turn Around Time
14 Days
Keywords
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["AKT1", "ARID1A", "ATM", "ATR", "BARD1", "BRAF", "BRCA1", "BRCA2", "BRIP1", "CDH1", "CDK12", "CHEK1", "CHEK2", "CTNNB1", "EGFR", "ERBB2", "ERBB4", "ESR1", "FANCA", "FANCC", "FANCD2", "FANCE", "FANCF", "FANCG", "FANCL", "FGFR1", "FGFR2", "FGFR3", "GATA3", "HRAS", "KIT", "KRAS", "MET", "MLH1", "MRE11", "MSH2", "MSH6", "NBN", "NRAS", "PALB2", "PIK3CA", "PMS2", "PTEN", "RAD50", "RAD51", "RAD51B", "RAD51C", "RAD51D", "RAD54L", "SMAD4", "SMO", "SRC", "TERT", "TP53"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["NTRK1", "NTRK2", "NTRK3", "PD-L1"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["MET"], "Deletion(s)": ["PTEN"]}}
Keywords string
Breast, Tumor, Profile, NeoTYPE Breast Tumor Profile NeoTYPE® Breast Tumor Profile
Title URL
neotype-breast-tumor-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.