Code
NTG-DRLX-02CX
Profile
Active-Compendium
81459x1. Add 88360x1 for PD-L1 IHC.
81479x1. If sample is insufficient to produce RNA fusion results but DNA SNV/indel and/or CNV results are reported, 81479x1 still applies. If only RNA fusion results are reported, use 81445x1 instead. Add 88360x1 for PD-L1 IHC.
Clinical
Oncology,Pathology
<p>A block is preferred for testing: >20% tumor and >5 mm2 of tissue surface area for NGS (~500 tumor cells)(additional 100 neoplastic cells for PD-L1). If submitting 5-micron unstained slides, the following number of slides are requested: Samples with >25 mm2 of tissue: 10 unstained slides (2 sections per slide preferred) Samples with 10-24 mm2 of tissue: 20 unstained slides (2 sections per slide preferred) Please submit 1 additional unstained slide for H&E and 3 additional unstained slides if performing PD-L1 testing.</p>
Flag Active
True
Orderable Test Description
<p>NeoTYPE® DNA & RNA – Lung is a targeted next‑generation sequencing profile that detects single nucleotide variants (SNV), insertions/deletions (InDels), copy number variants (CNV), and RNA fusions and splice variants in a total of <b>50 genes (44 genes analyzed by DNA and 19 by RNA)</b>, plus microsatellite instability <b>(MSI)</b> and tumor mutation burden <b>(TMB)</b>. Test results are summarized and details provided for prognostic findings, therapy susceptibility or resistance, available clinical trials, and more.<br><br>
If the sample is insufficient to produce either DNA or RNA results, the available results will be reported and alternate CPT® Codes may apply.<br><br>
<b>SNVs / Indels / CNVs (44 genes + MSI and TMB)</b><br>
The full coding sequence of each DNA gene is tested. <br>
Reflex rule: Microsatellite Instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥20% and paired normal tissue is available.<br><br>
<b>RNA Fusions / Splice Variants (19 genes)</b><br>
*Splice variant detection in addition to fusions. The full coding sequence of each RNA gene is tested.<br><br>
<b>IHC (1 biomarker) Optional</b><br>
PD‑L1 22C3 FDA for NSCLC (tech‑only available)</p>
If the sample is insufficient to produce either DNA or RNA results, the available results will be reported and alternate CPT® Codes may apply.<br><br>
<b>SNVs / Indels / CNVs (44 genes + MSI and TMB)</b><br>
The full coding sequence of each DNA gene is tested. <br>
Reflex rule: Microsatellite Instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥20% and paired normal tissue is available.<br><br>
<b>RNA Fusions / Splice Variants (19 genes)</b><br>
*Splice variant detection in addition to fusions. The full coding sequence of each RNA gene is tested.<br><br>
<b>IHC (1 biomarker) Optional</b><br>
PD‑L1 22C3 FDA for NSCLC (tech‑only available)</p>
Orderable Turn Around Time
8-10 Days
Orderable Biomarkers
NY Approved
True
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["AKT1", "ALK", "ARAF", "ARID1A", "ATM", "ATR", "ATRX", "BRAF", "CDKN2A", "CDKN2B", "EGFR", "ERBB2", "ERBB3", "ERBB4", "FBXW7", "FGFR1", "FGFR2", "FGFR3", "FGFR4", "KEAP1", "KIT", "KRAS", "MAP2K1", "MET", "NF1", "NFE2L2", "NOTCH1", "NRAS", "NTRK1", "NTRK3", "PDGFRA", "PIK3CA", "PTEN", "RB1", "RBM10", "RET", "ROS1", "SMAD4", "SMARCA4", "SMO", "STK11", "TERT", "TP53"], "Genomic Signatures": ["MSI", "TMB"]}, "RNA Sequencing": {"Fusions": ["ALK", "BRAF", "FGFR1", "FGFR2", "FGFR3", "FGFR4", "MET", "NOTCH1", "NOTCH2", "NRG1", "NTRK1", "NTRK2", "NTRK3", "PDGFB", "PDGFRA", "PDGFRB", "RAF1", "RET", "ROS1"]}}
Keywords string
DNA & RNA Lung, Lung DNA & RNA, Lung 2.0, DNA and RNA, Non-small cell lung cancer NeoTYPE® DNA & RNA - Lung
Title URL
neotype-dna-rna-lung
TAT Details
NGS: 8-10 Days
IHC: 2 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.