Code
NTG-LTPX-02CX
Profile
Active-Compendium
81457x1, 88377x5, 88360x2, 88342x1; add 88374x1 if HER2 IHC is reflexed to FISH; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
81479
Clinical
Oncology,Pathology
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Flag Active
True
Orderable Test Description
<p>The NeoTYPE® Lung Tumor Profile analyzes 51 biomarkers through a combination of next‑generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test reports include summary interpretation of all results to help guide treatment decisions.<br><br>
<b>NGS (40 genes + MSI and TMB)</b><br>
Reflex rule: A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available.<br><br>
<b>Other Molecular (1 biomarker)</b><br>
MET Exon 14 Deletion Analysis<br><br>
<b>FISH (5 biomarkers)</b><br>
ALK, MET, PTEN, RET, ROS1<br>
(tech‑only available)<br><br>
<b>IHC (3 biomarkers)</b><br>
<b>* HER2 (Other) IHC w/Breast Scoring</b> (tech‑only available)</b><br>
Reflex rule: If global HER2 (Other) IHC w/Breast Scoring result is 2+, case will reflex to global HER2 (Other) FISH w/Breast Scoring unless reflex to tech‑only FISH or reflex opt‑out is requested.<br>
<b>* PD‑L1 22C3</b> (tech‑only available)<br>
<b>* Pan‑TRK</b><br>
Reflex rule: If Pan‑TRK IHC is expressed or equivocal, reflex to either the NTRK NGS Fusion Panel (Default) or the NTRK 1–3 FISH Panel will be added.</p>
<b>NGS (40 genes + MSI and TMB)</b><br>
Reflex rule: A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available.<br><br>
<b>Other Molecular (1 biomarker)</b><br>
MET Exon 14 Deletion Analysis<br><br>
<b>FISH (5 biomarkers)</b><br>
ALK, MET, PTEN, RET, ROS1<br>
(tech‑only available)<br><br>
<b>IHC (3 biomarkers)</b><br>
<b>* HER2 (Other) IHC w/Breast Scoring</b> (tech‑only available)</b><br>
Reflex rule: If global HER2 (Other) IHC w/Breast Scoring result is 2+, case will reflex to global HER2 (Other) FISH w/Breast Scoring unless reflex to tech‑only FISH or reflex opt‑out is requested.<br>
<b>* PD‑L1 22C3</b> (tech‑only available)<br>
<b>* Pan‑TRK</b><br>
Reflex rule: If Pan‑TRK IHC is expressed or equivocal, reflex to either the NTRK NGS Fusion Panel (Default) or the NTRK 1–3 FISH Panel will be added.</p>
Orderable Turn Around Time
14 Days
Orderable Biomarkers
NY Approved
False
Orderable Biomarkers JSON
{"DNA Sequencing": {"SNVs + Indels": ["AKT1", "ALK", "ARID1A", "ATM", "ATR", "ATRX", "BRAF", "CCND1", "CDKN2A", "CDKN2B", "EGFR", "ERBB2", "ERBB4", "FBXW7", "FGFR1", "FGFR2", "FGFR3", "KEAP1", "KIT", "KMT2D", "KRAS", "MET", "NF1", "NFE2L2", "NOTCH1", "NRAS", "PDGFRA", "PIK3CA", "PTEN", "RB1", "RBM10", "RET", "ROS1", "SMAD4", "SMARCA4", "SMO", "SRC", "STK11", "TERT", "TP53"], "Genomic Signatures": ["MSI", "TMB"]}, "Immunohistochemistry (IHC)": {"Expression": ["HER2", "NTRK1", "NTRK2", "NTRK3", "PD-L1"]}, "Fluorescence In Situ Hybridization (FISH)": {"Amplification(s)": ["HER2", "MET"], "Deletion(s)": ["PTEN"], "Rearrangement(s)": ["ALK", "RET", "ROS1"]}, "Polymerase Chain Reaction (PCR)": {"Splice Variant": ["MET Exon 14 Deletion"]}}
Keywords string
precision profile, solid tumors, neo type, NeoTYPE Precision Profile for Solid Tumors. NeoTYPE® Lung Tumor Profile
Title URL
neotype-lung-tumor-profile
TAT Details
NGS: 14 Days
FISH: 7 Days
IHC: Global: 2 Days
Tech-Only (stain
only): 24 Hours
Potential Reflex Testing (Additional Time):
MSI by PCR: 5 Days
HER2 FISH: 5 Days
NTRK 1-3 FISH: 5 Days
NTRK NGS: 1-3 Days
Storage and transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.